Diagnosing Rare Instances of Mammary Gland Diseases Using

NLS-Investigation

S.N. Okunev,

K.S. Kogan

This article deals with some clinical observations of rare cases of mammary gland

diseases detected by means of nonlinear diagnosis method (NLS) during clinical

diagnostic prophylactic investigations performed in October 2001 with the purpose of an

early diagnosis. In the course of the activity the patients were found to have different

diffuse or nodal mammary gland diseases among which of particular interest are some

rare diseases like liposarcoma (1 case), colloidal cancer (1 case), phyllode cystosarcoma

(1 case), phyllode fibroadenoma (2 cases), hemanglomma (1 case) and Mondore’s

syndrome (1 case).

According to some literary evidence, colloidal cancer and lipo-sarcoma do not occur very

often among malignant tumors: colloidal cancer in 2.4% and lipo-sarcoma in 0.001-

0.03% of cases respectively. Among benign tumors hemangloma occurs in 0.12%,

phyllode fibroadenoma in 5.4% and phyllode cystosarcoma in 2.5-5.4% of cases. The

investigation was done using A NLS device with a 4.9Ghz nonlinear sensor under the

program of virtual tissue representation of panoramic scanning (Panoramic NLS

Imaging).

Mammary gland lipo-sarcoma

Patient G., aged 28, was admitted having complaints of a nodal formation in her left

mammary gland. During the examination an umbilication symptom in the upper outside

guardant of the left mammary gland was discovered. The palpation detected a small-

sized painless sluggish node of a dense elastic consistency that had a dotted structure and

adhered to the skin. By means of a detailed imaging the investigation ascertained a node of

15-20 mm in diameter and detected its spectral similarity to the reference standard

‘mammary gland lipo-sarcoma’ (D=0.204). The investigation of the regional lymph

nodes did not detect any metastatic lesion.

Based on the NLS-investigation data a surgery (medical mastectomy according to

Maden’s method) was performed. The histological diagnosis was lipsarcoma.

Colloidal mammary gland cancer

Patient K., aged 49 was admitted as having complaints of a node in the left mammary

gland.

The examination did not produce any visible evidence of changes in the mammary

glands. A sluggish roundish formation with a diverse consistency and vague outlines was

palpated on the border between the upper quadranis of the left mammary gland.

45The NLS-investigation detected a roundish formation (6 points according to Flandler’s

scale). The graph examination showed spectral similarity to the reference standard ‘solid

cancer’

.

The patient underwent surgery, a radical mastectomy was performed according to

Moden’s technique. The histological conclusion was colloidal cancer.

Phyllode mammary gland cystosarcoma

Patient G., aged 46 was admitted as having complaints of a slow growth dense node in the

right mammary gland.

Palpation detected in the upper outside guardant of the right mammary gland a painless

motionless formation with a diverse density and heterogeneous surface that adhered to

the skin.

The NLS-investigation detected an irregular 3x6x4 cm formation. A spectral similarity to the

reference standard ‘mammary gland sarcoma’ (D=0.412) was found. Its small size allowed to

completely visualize the involvement of lymph nodes.

The patient underwent surgery - radical mastectomy according to Moden’s technique.

The histological diagnosis was phyllode cystosarcoma.

Phyllode mammary gland fibroadenoma

Patient Z., aged 43 was admitted as having complaints of a large node in the right

mammary gland.

The examination showed asymmetry of the mammary glands.

On the border between the outside quadrants of the right mammary gland a mobile node of a

large node with distinct outlines and smooth surface and tight elastic consistency was

palpated. The skin above the tumor was very thin.

The NLS-investigation detected some hyper-chromous structures corresponding to

The analysis of the graphs detected a similarity to the reference standard

intranodal vessels. ‘fibroadenoma’ (d=0.384).

On the strength of the NLS-investigation subcutaneous amputation of the right mammary

gland and omento-mammoplaty on a vascular pedicle were performed. The histological

diagnosis was phyllode fibroadenoma.

After the plastic surgery (one month later) a repeated NLS-investigation was carried out.

46Mammary gland hemangioma

Patient C., aged 42 was admitted as having complaints of a large size node in the right

mammary gland.

During the examination it was found out that the skin over the node had a cyanotic cast. On

the border between the upper quadrants a mobile formation with a soft consistency was

palpated. The graph analysis detected a similarity to the reference standard

‘hemangioma’ (D=0.414).

The patient underwent surgery i.e. a sectoral resection was performed. The histological

diagnosis was cavernous hemangioma.

The presented clinical observations showed that the continuous improvement of

NLSsystems and the modern technologies made it possible to introduce a morphological

picture of the neoplasm which helps devise the optimal tactics of surgery with further

morphological verification of the derived results.